Is RNA Critical for the Production of TSE Infection?
نویسنده
چکیده
average length of about 27 and 55 nucleotides. The association of these RNAs with recPrP reconstituted an infectious TSE agent showing in hamster brain strain characteristics slightly different from 263 K infectious agent (Simoneau et al., 2009). As currently recognized, the demonstration of the prion hypothesis should be performed in wild-type (wt) animals. However I suggest that comprehensive proof of the causal agent of TSEs is composed exclusively of an infectious PrP protein can only be obtained when experimentation meets four requirements. This tetrad of rules is equivalent to Koch’s postulates for microbial agents, namely that:
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عنوان ژورنال:
دوره 1 شماره
صفحات -
تاریخ انتشار 2010